Pharmacokinetic evaluation of single-dose intravenous daptomycin in patients with thermal burn injury.
نویسندگان
چکیده
Daptomycin pharmacokinetics were evaluated for burn patients. Burn patients had decreases in the maximum concentration of the drug in serum (44%) and the area under the concentration-time curve (47%) and increases in the volume of distribution (64%) and total clearance (77%) compared to healthy volunteers. In burn patients, daptomycin at 10 to 12 mg/kg of body weight/day would be required to achieve drug exposures similar to those for healthy volunteers receiving 6 mg/kg.
منابع مشابه
Comparison of the pharmacokinetics, safety and tolerability of daptomycin in healthy adult volunteers following intravenous administration by 30 min infusion or 2 min injection
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 52 5 شماره
صفحات -
تاریخ انتشار 2008